Many new trailers, in an effort to save money, are equipped with inferior foreign tire brands. In addition, many heavy trailers are running at their maximun weights with tires and axles that are barely adequate for the task. They often have little of no reserve capacity.

Most trailer tires are not rated for speeds in excess of 65 MPH. Many trailer owners I've encountered exceed that recommendation. Maintaining correct tire pressures is absolutely manditory. Any underinflation with a heavy load will increase the heat in the sidewalls,  causing the threads to delaminate and the tire to blow out. Inexpensive tires will dry rot quickly, weakening the carcass. The age of the tires should not exceed 6 or 7 years regardless of mileage.

The tires should be inspected every trip for abnormal wear. This will indicate an alignment problem caused by an impact or undercarriage malfunction.

Whenever possible with the "E" weight 16" tires, I recommend replacing them with LT truck tires. I've never had a trailer blow out whilst using these replacements.

It is essential that the trailer rides LEVEL front to back.   If your trailer has torflex axles and rides nose high (common) the rear axle carries  way more than half of the load.  If your total trailer load is close to the maximum the rear axle may be overloaded substantially.  This causes LOTS of tire issues. A easy check for this is hand checking tire temperature when you pull off the highway.   If the rear tires are notacably warmer than the front there is unequil loading.